IVF treatment with PGD/PGS might be an option for infertile couples who, despite all efforts, have still not become pregnant and whose diagnostic findings seem to be linked to the failure. However, the option is only available for couples who meet all the medical and legal requirements.
Basically, there are two terms for the aforementioned investigations, though referring to two distinct techniques (for more details see “links”). On the one hand, there is “Pre-Implantation Genetic Diagnosis” (PGD) – in German-speaking countries also referred to as “Pre-Implantation Diagnosis” (PID). On the other hand, there is “Pre-Implantation Genetic Screening” (PGS). These are analytic diagnostic procedures that may, for instance, be used in cases of individuals who are known carriers of a genetic disorder and/or have a history of a genetic disease in the family, recurrent miscarriage or multiple failed IVF attempts.
This underlines the importance of ensuring comprehensive consulting and clarification of the couple’s initial situation by an experienced medical specialist. Dr. Maximilian Murtinger, Medical Director of the IVF Centers Prof. Zech – Bregenz, is familiar with the questions that preoccupy the couples concerned: Artikel lesen
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FAQs on genetics within the context of fertility treatment
“It had finally worked out and I became pregnant with our little ‘polar bear’. Since yesterday, we are the proud parents of a healthy baby girl and we couldn’t be more thrilled.”
In this way or in a very similar one, couples talk about their experiences gained during IVF treatment involving a so-called ‘cryo cycle’. The procedure comprises the initial freezing of the embryo (fertilized oocyte in the early stages of its embryonic development) in order to thaw it at a later point in time and transfer it to the uterus (embryo transfer).
But why does the attending doctor opt for this kind of therapy? Artikel lesen
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Cryo cycle after IVF
The aim of this medical specialty can already be inferred from the term Reproductive Medicine. It means understanding and copying nature right down to the smallest details, i.e. supporting human procreation using medical-technical procedures designed to help sub-fertile couples. Based on current scientific knowledge, an important role is played by a treatment option called blastocyst culture.
During a thorough medical consultation at the beginning of each fertility treatment, the doctor, together with the couple, will decide on the most suitable form of treatment, based on laboratory results, diagnostic findings etc. Details on the medical indication, legal framework conditions as well as on the sequence of the treatment will also be taken into account during this consultation. Artikel lesen
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IVF treatment involving blastocyst culture
The couples’ requirements may vary considerably when it comes to achieving a pregnancy via egg donation.
There are situations where couples cannot achieve a successful pregnancy with the woman’s own oocytes (e.g. cancer treatment, genetic diseases, premature menopause) and would therefore have to consider IVF treatment with egg donation.
First, however, each couple’s initial situation has to be assessed in a professional and comprehensive way and any questions the couple may have must be answered. For example by MUDr. Libor Hradecký Ph.D., the Medical Director of the IVF Centers Prof. Zech in the Czech Republic. For 15 years now, he and his Pilsen-based team have helped couples realize their dream of having a child through IVF treatment with donor eggs.
As an experienced practitioner of reproductive medicine, he knows about the issues couples considering this kind of treatment are most concerned about: Artikel lesen
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FAQs on egg donation
Precisely tailored to the woman’s individual situation, her body is prepared for pregnancy prior to receiving fertility treatment. The ovaries are stimulated with hormones, which is an important first step towards the long-awaited child.
The targeted administration of hormones is intended to induce the maturation of multiple follicles, each containing an oocyte. In medical terms, this kind of treatment is referred to as ovarian stimulation (→ details). Artikel lesen
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Hormonal stimulation in fertility treatment
When analyzing success rates in fertility treatment, it often turns out that the stated values refer to cumulative pregnancy rates. But what exactly is meant by this type of pregnancy rate?
Cumulative is derived from the Latin word “cumulare” (to accumulate).
According to experts, the cumulative pregnancy rate takes account of all pregnancies achieved by IVF following several successive embryo transfers. Irrespective of whether these embryos derive from so-called “fresh cycles” (the fertilized oocyte develops inside an incubator and is usually transferred to the uterus on the fifth day of embryonic development) or from “cryo cycles” (for some reasons, the growing embryo can be frozen/cryopreserved, the frozen-thawed embryo can then be used in a future transfer).
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Part 5 of the topic-series »Success Rate«
Before and during fertility treatment, patients are often faced with a lot of impressions and information. Sometimes, however, this can be highly confusing, giving rise to a large number of questions.
After asking around, I discussed the issues with Univ. Prof. Dr. Herbert Zech, a specialist in reproductive medicine and founder of the IVF centers of the same name. Below please find his answers to some frequently asked questions:
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FAQs on fertility treatment
Sperm-Check using a smartphone app, ovulation tests, testing of hormone levels using ready-to-use test kits …
Fertility tests for self-/home testing are not entirely new, but obviously there are ever more inventive products featuring supposedly greater user friendliness. This, of course, arouses the interest of many men and women.
US researchers have recently presented a prototype of an accessory for smartphones that allows to analyze a semen sample for sperm concentration and motility (according to WHO criteria) using an appropriate App. The goal is to offer a fertility test for men that is simple and reasonably priced in the same way as are pregnancy tests, the scientists say.
But do such tests for men who wish to conceive a child actually provide sufficiently meaningful results? Artikel lesen
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When it comes to choosing an IVF center, among other things, couples seeking fertility support want to learn more about the clinic’s performance figures (e.g. pregnancy rate, live birth rate). In some countries, IVF centers are required by law to publish their results and make them freely available. In countries where this is not the case, the disclosure of such data occurs on a voluntary basis. In both cases, for most couples the following question arises when taking a closer look at the outcomes presented:
“But what does this actually mean for us?” Artikel lesen
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Part 1 of the topic-series »Success Rate«
“If there’s a way to do it better: find it.”
Thomas A. Edison (1847-1931)
If we interpret this quote by Thomas Edison, the continual pursuit of improvements may (as, for example, in the case of Edison) lead to new inventions or to the improvement of already existing technologies.
It is a matter of finding ways, enabling us to achieve a certain quality standard that is subject to constant review and improvement. This requires an established structure, for example with respect to the workflows in a company.
Here, experts are referring to quality management systems aiming, among other things, at implementing appropriate measures and building up a trusting relationship with customers.
What exactly is meant by this when dealing with the working procedures of an IVF center?
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Application and Relevance of a Quality Management System
Infertility Possible causes in women
Possible causes in men
Why is age a reason for?
Fertility treatment Hormonal stimulation
Pre-Implantation Genetic Diagnosis (PGD)
"Social Freezing" / "Medical Freezing"
Fertility treatment processPart 1 | Initial Consultation
Part 2 | Ovarian Stimulation
Part 3 | Ultrasound Scan
Part 4 | Egg retrieval
Part 5 | Embryo Transfer
Success rate - What to look forPart 1 | "What does this mean for us?"
Part 2 | Assessing the chances
Part 3 | Pregnancy rate
Part 4 | Implantation rate
Part 5 | Cumulative pregnancy rate